ITGAL and Cognitive impairment: LFA-1-deficient 3xTg mice or normal 3xTg mice treated with an anti-LFA-1 mAb showed reduced cognitive impairments in the Y-maze and reduced accumulation of IBA1 + cells in the hippocampus along with reduced levels of Aβ plaques (Figure 1; Zenaro et al., 2015).