In the Cox proportional-hazards model, advanced age and presence of APOE ε4 genotype were associated with increased risk of incident dementia among clinical predictors (model 1) (APOE ε4; HR 8.53; 95% CI 1.43–50.70; p = 0.018), and APOE ε4 was correlated with increased risk of dementia after the adjustment for MRI predictors (model 3) (HR 10.7; 95% CI 1.27–89.88; p = 0.029). This evidence concerns the gene APOE and dementia.