In the sensitivity analyses of the 82 patients with p.Arg544Cys mutation, SBP, and APOE ε4 genotype remained significant for increased risk of incident stroke (HR 1.49; 95% CI 1.08–2.06; p = 0.016) and dementia (HR 10.97; 95% CI 1.41–85.61; p = 0.022) in adjusted analyses (Figure 3). The gene discussed is APOE; the disease is Stroke.