Resveratrol modulates various cellular responses such as lipid droplet accumulation and insulin resistance and regulates diverse cellular signalings including AMPK, cAMP, and NF-κB signaling and also controls the balance of neurotransmitters such as BDNF and 5-HT, involved in both the progression of neuropathology and gut homeostasis. The gene discussed is BDNF; the disease is Insulin resistance.