MAPT and Alzheimer disease: Compared with the WT group, Tau phosphorylation in the AC group was elevated (F(3, 20) = 106.2, p < 0.0001 for p-Tau MFI/cell number; F(3, 20) = 72.59, p < 0.00013 for p-Tau/total Tau), but the elevation was significantly blocked by LSZ treatment (F(3, 20) = 106.2, p < 0.0001 for p-Tau MFI/cell number; F(3, 20) = 72.59, p < 0.0001 for p-Tau/total Tau), although neither the AD model nor LSZ treatment had an effect on Tau expression (Figure 7).