To further understand the correlation between the inflammatory response and the pathogenesis of PD, we constructed 6-OHDA-induced PD rat models, and detected the relative expression of P2X4R and IL-6, and the number of TH positive DA neurons in the SN of rats, and observed the changing trend of the above results after P2X4R overexpression. Here, P2RX4 is linked to Parkinson disease.