TNF and Parkinson disease: The autopsy revealed the amounts of different inflammatory factors including Tumor Necrosis Factor-α (TNF-α), IL-1β, IL-2, IL-4, IL-6 were notably higher both in the striatum and in cerebrospinal fluid of PD than the normal (Mogi et al., 1995; 1996a,b; Nagatsu et al., 2000).