Human Urinary Kallidinogenase (HUK) acts as a potential neuroprotectant, functioning to increase the expression of VEGF and promote angiogenesis and neuronal regeneration in hypoxic-ischemic encephalopathy (HIE) models, which may be an alternative treatment to PD (Gao et al., 2018). The gene discussed is VEGFA; the disease is perinatal asphyxia.