Especially, body fat percentage, leptin and insulin resistance are among other indicators of increased fat mass and might thus be associated with chronic low-grade inflammation in obesity (Jung and Choi, 2014; Chen et al., 2015; Saad et al., 2016; La Cava, 2017; Reilly and Saltiel, 2017). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.