DISC1 and psychiatric disorder: In addition, PDE4D interacts with another risk gene for mental illness, Disrupted in Schizophrenia 1 (DISC1) (Murdoch et al., 2007; Chubb et al., 2008), which anchors PDE4s to the SER where it can regulate cAMP drive on internal calcium release (Kirkpatrick et al., 2006; Paspalas et al., 2013).