The major components of RFs in AxD are mutated GFAP (i.e., R239C or R416W GFAP), vimentin, αB-crystallin, and hsp27 (small heat shock proteins) (Der Perng et al., 2006; Heaven et al., 2016; Sosunov et al., 2017). The gene discussed is GFAP; the disease is Alexander disease.