IFNA1 and Aicardi-Goutieres syndrome: To confirm this theory and to gain additional insights in glial crosstalk in AGS, a direction for future research could be to expose astrocytes to double-strand RNA (dsRNA) polyinosinic:polycytidylic acid (poly I:C) (this is expected to upregulate their production of IFNα) and subsequently assess the consequences for oligodendrocyte functionality in a coculture setup.