B-cells from MS patients show an increased expression of APC-related markers (Sospedra, 2018; Guan et al., 2019) and experiments in EAE mice uncovered that EBV upregulates antigen cross-presentation of infected B-cells to CD8+ T-cells (Dunham et al., 2017; Jakimovski et al., 2017). This evidence concerns the gene CD8A and myeloid sarcoma.