Altogether, these data show that the status of DCs is crucial for MS development, i.e., steady-state DCs play a protective role by inducing self-tolerance and by differentiating Treg cells, whereas activated DCs are responsible for the stronger immunogenic response by activating CD4+ T-cells (Greter et al., 2005; Yogev et al., 2012; Mohammad et al., 2013). The gene discussed is CD4; the disease is myeloid sarcoma.