For example, given that impaired intrinsic plasticity or degeneration of Purkinje neurons is associated with ataxia and STIM1 knockdown is linked to impaired intrinsic plasticity (Ryu et al., 2017; Ady et al., 2018; Hoxha et al., 2018), deficiency of STIM1-mediated SOCE could be a potential cause of ataxia. The gene discussed is STIM1; the disease is cerebellar ataxia.