Growing evidence shows that SOCs play an important role in neuronal signaling and plasticity, and have been implicated in neurological disorders (Kraft, 2015; Majewski and Kuznicki, 2015; Lu and Fivaz, 2016; Bollimuntha et al., 2017; Wu H. E. et al., 2018; Alvarez et al., 2020). Here, CISH is linked to nervous system disorder.