MAPT and glioblastoma: In GBM, secreted CD44 leads to hyperphosphorylation of Tau in the hippocampus (Lim et al., 2018); furthermore, besides this neurodegenerative property, Tau was implicated in GBM cells spreading: Tau expressed in GBM cells increases their motility by modulating cytoskeleton dynamics in a Rho-associated protein kinase (ROCK) signaling pathway-dependent manner, it stabilizes microtubules, and generates a rearrangement of the location of ROCK signaling pathway molecules, leading to active actin cytoskeleton dynamics and motility (Breuzard et al., 2019).