These miRNAs, enriched in glioma-derived exosomes, have a great impact on microglia, where they reduce c-Myc expression, a transcription factor regulating several cellular processes including cell cycle and apoptosis, and promote a shift toward an immune suppressor phenotype, supporting glioma progression (Van Der Vos et al., 2016; Guo et al., 2019). This evidence concerns the gene MYC and central nervous system cancer.