SOD1 and amyotrophic lateral sclerosis: One compound, TRVA242 was identified as the most effective compound and rescued locomotion, improved motor neuron survival, and rescued neuromuscular junction deficits in the aforementioned C. elegans and zebrafish model, as well as in SOD1 and C9ORF72 zebrafish models of ALS, and in SOD1-G37R mice.