SOD1 and Motor neuron atrophy: Intraperitoneal injection of bosutinib (5 mg/kg) into transgenic SOD1-G93A mice daily starting at 8 weeks of age for 5 weeks, reduced misfolded SOD1 and motor neuron degeneration in spinal cords, as well as delaying disease onset by 10.8 days and extending survival by 7.8 days (Imamura et al., 2017).