TARDBP and amyotrophic lateral sclerosis: Indeed, it is clear that TDP-43 can adopt an amyloid-like state in relevant tissues from ALS and FTLD patient samples as shown by immunoelectron microscopy (Lin and Dickson, 2008; Thorpe et al., 2008) and Thioflavin-S staining of carefully processed samples (Bigio et al., 2013; Robinson et al., 2013).