Using a luciferase-based fluorescence assay to measure TDP-43 inclusions in the murine Neuro-2a neuroblastoma cell line, Oberstadt et al. (2018) screened the LOPAC1280 library (Sigma–Aldrich) and found 16 active compounds that reduced TDP-43 dimerization by 30–82%. Here, TARDBP is linked to neuroblastoma.