SOD1 and amyotrophic lateral sclerosis: In regards to both proteostasis and prion-like propagation, the consensus of this work suggests that ALS-associated mutations can have specific destabilizing effects on SOD1 structure, resulting in a greater proportion of the protein populating an ensemble of non-native states and, therefore, is susceptible to aggregation and prion-like conversion (McAlary et al., 2019b; Wright et al., 2019).