TARDBP and amyotrophic lateral sclerosis: Interestingly, these mice homologous for these transgenes show motor deficits and in some cases, motor neuron loss in the absence of mislocalized TDP-43, suggesting TDP-43 mislocalization may not be the cause of motor neuron toxicity in ALS (Fratta et al., 2018; White et al., 2018; Ebstein et al., 2019; Gordon et al., 2019).