SOD1 and amyotrophic lateral sclerosis: Furthermore, ALS-associated mutations augment the fibrillation of SOD1 to different degrees (Furukawa et al., 2008, 2010; Lang et al., 2012; Chan et al., 2013; Abdolvahabi et al., 2016, 2017; McAlary et al., 2016), whereas some de novo mutations and PTMs have been shown to prevent (Abdolvahabi et al., 2015; Rasouli et al., 2017; Pokrishevsky et al., 2018) or enhance fibrillation (Shi et al., 2013).