HSPA8 and amyotrophic lateral sclerosis: Interestingly, expression of ALS-linked mutant forms of hTDP-43 leads to locomotor defects that can be rescued by over-expression of wild-type Hsc70–4, but not mutant forms that are defective in chaperone (Hsc70–4D10N) or microautophagy functions (Hsc70–43KA).