A study investigated the autoimmune condition of a girl with a rare triad of RP, Coats disease and uveitis, and found that her peripheral lymphocytes had a specific anamnestic response to IRBP (Solomon et al., 1999), indicating that autoimmunity toward IRBP might play a role in the degeneration of photoreceptors. Here, RBP3 is linked to retinitis pigmentosa 1.