TREM2 and Alzheimer disease: The role of TREM2 has been mainly reported in chronic experimental models of AD and other chronic disorders—like experimental autoimmune encephalomyelitis (EAE, reviewed in Karanfilian et al., 2020)—and, to a lesser extent, in different acute neuroinflammatory conditions, including cuprizone-induced demyelination, stroke, and traumatic brain injury, among others (reviewed in Deming et al., 2018).