MAP1LC3A and Alzheimer disease: In a study by Ulland et al., increased LC3+ puncta, an autophagosome marker, was observed in human post-mortem brain sections from AD patients with a rare R47H variant of the Trem2 gene compared to controls (Ulland et al., 2017; Filipello et al., 2018; Ulland and Colonna, 2018).