Accelerated sarcopenia and a shortened lifespan were observed in mice with low levels of the spindle assembly checkpoint protein BubR1, including Bub1bH/H mice with two hypomorphic alleles and Bub1b+/GTTA mice with the human nonsense mutation 2211insGTTA (Baker et al., 2004; Wijshake et al., 2012). This evidence concerns the gene BUB1B and sarcopenia.