Although PYY, GLP-1 and GIP are secreted peripherally from the gastrointestinal tract, they cross the blood-brain barrier (Banks and Kastin, 1998; Kastin et al., 2002; Nonaka et al., 2003; Dogrukol-Ak et al., 2004) and have receptors in many brain regions, including those involved in the metabolic response and affected in AD, such as the hypothalamus, temporal and parietal cortex, and hippocampus (Martel et al., 1990a; Usdin et al., 1993; Dumont et al., 1996; Jhamandas et al., 2011). The gene discussed is GIP; the disease is Alzheimer disease.