In GBM, a downregulation of Kir4.1 during the early stage of the tumor progression has been reported (Olsen and Sontheimer, 2004; Ratto et al., 2019), which is correlated to the dramatic shift in RMP of GBM cells to more depolarized values around −40/−30 mV (Olsen and Sontheimer, 2004). Here, KCNJ10 is linked to glioblastoma.