Several genetic mutations have been identified in genes namely, APP, presenilin 1/2 (PS1/2), and APOE, to cause Familial Alzheimer’s disease (Armstrong, 2013; Karch et al., 2014; Shen, 2014; Moreno et al., 2018; Wang et al., 2018). Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.