CHGA and adenocarcinoma: In addition, epithelial cells of patient #6 consisted of a group of NE cells (cluster 4, expressing ASCL1, CHGA, and CHGB), a group of basal cells (cluster 8, expressing KRT5, KRT14, and KRT15) as well as the remaining ARhigh luminal cells, presenting mixed features of both adenocarcinoma and NEPC (Fig. 3B).