However, our analysis in PC TMAs reveals that only about 1% of patients (1/102) contain SYP+ cells that express both K8 and K5 in adenocarcinoma tissues argue strong for the notion that such direct basal-NE transdifferentiation is likely rare in human prostate cancer, but rather luminal-NE transdifferentiation is fundamentally responsible for phenotypic transition from acinar adenocarcinomas toward NEPC. This evidence concerns the gene KRT5 and acinar cell carcinoma.