Interestingly, a recent cell lineage tracing study using TRAMP mouse models (p63-CreERT2;Rosa-LoxP-STOP-LoxP-tdRFP;TRAMP and K8-CreERT2;Rosa-LoxP-STOP-LoxP-tdRFP;TRAMP) has demonstrated that NEPC is directly originated from basal progenitor cells but not luminal cells or pre-existing KRT8+ adenocarcinoma cells15. The gene discussed is KRT8; the disease is adenocarcinoma.