Re-clustering epithelial cells from each tumor combined with heatmap analysis showed that epithelial cell sub-clusters from each sample highly expressed luminal cell markers such as KRT8 and KRT18, while the expression of basal, NE, and AR signature genes exhibited apparent intra- and inter-tumor heterogeneity (Fig. 3A, B and Supplementary Data 3). This evidence concerns the gene KRT18 and neoplasm.