Recently, in vivo lineage tracing of proximal tubule KIM1 + cells (a marker specific for injured proximal tubule cells) early following acute kidney injury and clonal analysis, revealed clonal expansion and co-expression of KIM1, VIMENTIN, SOX9, and MKI67 in their derived clonal progeny, suggesting concomitant mesenchymal dedifferentiated and proliferative states of these clonal cells8. This evidence concerns the gene HAVCR1 and acute kidney injury.