First, as discussed, we only have indirect evidence to support the role of EOS-derived IL4 in cardiac fibrosis by regulating EOS mEar1 expression, although IL4 did block H2O2-induced cardiomyocyte death, and EOS-deficient ∆dblGATA mice at 1-day and 1-month post-MI had significantly reduced heart IL4 levels. This evidence concerns the gene IL4 and myocardial infarction.