Nine loci surpassed the genome-wide significance threshold (Fig. 1, Table 1 and Supplementary Fig. 1), of which the FUT2/MAMSTR locus on chromosome 19, with the top SNP rs281379 (odds ratio (OR) = 1.18 (95% confidence interval (CI) = 1.11–1.25), Pdiscovery = 2.6 × 10−9) (Supplementary Fig. 2), emerged as a novel locus associated with asthma. This evidence concerns the gene FUT2 and asthma.