We exemplify the value of the data resource generated by linking a putative genomic risk variant for poor prognosis among COVID-19 patients, i.e., respiratory failure, at the ABO locus10 to proteins related to the maladaptive response of the host, namely hypercoagulation, as well as two putative viral interaction partners (heme oxygenase 1 and PLOD2). The gene discussed is HMOX1; the disease is respiratory failure.