Meanwhile, both the combination of intraamniotic LPS + Beta-Ac and term animals showed suppression of genes related to developmental pathways of lung development relative to control, including FGF9 and FGF10. Both fibroblast growth factors are essential for lung development, and KO of either FGF9 or FGF10 causes early neonatal mortality due to lung hypoplasia (47, 48). This evidence concerns the gene FGF9 and Pulmonary hypoplasia.