Differential network analysis (Ideker & Krogan 2012) directly identifies the relationships selectively lost in BRAF-mutant cells, such as that between EGFR and BRAF, and provides an explanation why pan-cancer coessentiality analysis fails to identify strong relationships between EGFR/KRAS and downstream MAPK pathway genes (Fig 5C, bottom right panel). This evidence concerns the gene KRAS and cancer.