HSF1 and cancer: We built a pan-cancer coessentiality network for HSF1 (Fig 6A), which was enriched for genes involved in protein homeostasis (e.g., HSPA4/Hsp70, DNAJB6/Hsp40, HSPA14/Hsp110, and FKBPL), but also contained genes involved in transcription (e.g., ELP1 and ELP2) and cell cycle regulation (e.g., CENPA and CEP135).