CDK2 and cancer: CDK2 subtype, specifically, received a great attention as a therapeutic target for cancer treatment due to its key role in several cellular processes upon complexation with its activating cognate, cyclin A or E, in addition, dysregulation of CDK2 or its cyclin partners was detected in various cancers such as ovarian, lung, pancreatic carcinomas, melanoma as well as breast cancer 23–27,.34–37