The overexpression of GSK-3β correlates with poor prognosis in patients with breast cancer28–29, moreover, aberrant nuclear accumulation of GSK-3β in five human breast cancer cell lines and in 70% of human breast carcinomas was reported29, furthermore, GSK-3β inhibition suppressed the viability of breast cancer cells in vitro, moreover, GSK-3β inhibition overcomes chemoresistance in human breast cancer.52 Here, GSK3B is linked to breast carcinoma.