APP and Cognitive impairment: The protective effect of Sig-1R has also been observed in two AD mice models (3xTg-AD and MacGill-R-Thy1-APP), where the treatment with a Sig-1R agonist, named AF710B (a concomitant agonist of the muscarinic 1 receptor), have been shown to restore cognitive impairment, and to reduce amyloid pathology and neuroinflammation [112,113].