The tight association of EMT with an increase of malignancy of lung adenocarcinoma is evidenced by the fact that overexpression of mesenchymal-type related N-cadherin and Twist1 was correlated with a shorter overall survival [61] as well as vimentin expression can serve as a prognostic biomarker for the metastases [62] in non-small cell lung adenocarcinoma patients. This evidence concerns the gene TWIST1 and non-small cell lung adenocarcinoma.