Here, we reported that SM showed the most pronounced inhibitory effect on a motility of murine melanoma B16 and human lung adenocarcinoma A549 cells compared to other investigated cyano enone-containing compounds and effectively blocked TGF-β-induced EMT of A549 cells, by inhibiting of a range of events triggered by this growth factor. Here, TGFB1 is linked to lung adenocarcinoma.