EGF and neoplasm: These cells can secrete an array of growth factors and cytokines, such as transforming growth factor β (TGF-β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), interleukin 6 (IL-6) and others, which bind to the corresponding receptors exposed on the surface of tumor cells and thereby activate a complex network of signaling pathways with subsequent up-regulation of EMT-associated transcription factors ZEB1/2, Snail, Slug and Twist1/2 that orchestrate EMT program [1,5].