Therefore, our results indicate that L. paracasei DTA81 can mitigate the precedent stages involved in CRC development, although additional investigations are needed adopting a long-term study with a larger cohort to evaluate further biomarkers of colon carcinogenesis such as aberrant crypt foci (ACF) formation and related pathways such as Apc/β-Catenin and K-Ras. This evidence concerns the gene KRAS and colorectal carcinoma.