Another factor contributing to CRC development concerns the continuous local inflammatory process, evident in inflammatory bowel disease (IBD), which consists of cellular and humoral responses via increased production of pro-inflammatory cytokines such as IL-6, IL-17, interferon-gamma (IFN-γ), and tumor necrosis factor (TNF-α) in an attempting to regenerate the injured tissue [5,6]. Here, TNF is linked to colorectal carcinoma.