Among them, Swierkot et al. [127] analyzed five SNPs in the TNFα and TNFR genes (TNFα-G308A, -G238A, and -C857T; TNFR1A-G36A and TNFR1B-T676G), finding that, after a 6-month therapy, RA patients with TNFR1A-36AA genotype showed a better response than those who were TNFR1A-36GG homozygotes. This evidence concerns the gene TNFRSF1B and rheumatoid arthritis.