ATIC and rheumatoid arthritis: Examining nine comparative studies including 1056 RA patients, the authors found that ATIC 347 GG + GC genotype was associated with the lack of response to MTX (OR = 1.884, 95% CI = 1.236–2.873, p = 0.003) and with MTX-related toxicity in Caucasian RA patients (OR = 1.741, 95% CI = 1.080–2.806, p = 0.023) [105].