In SCLC cells subjected to the cisplatin-based chemotherapy, EZH2 complexes with the DDB1-DDB2 heterodimer and promotes DDB2 stability by impairing its ubiquitination, thereby facilitating DDB2 localization to cyclobutene pyrimidine dimer crosslinks for their repair [80]. The gene discussed is EZH2; the disease is small cell lung carcinoma.