HIF1-α induction upon hypoxia results in PRC2 inactivation by selective suppression of the expression of SUZ12 and EED, and then, EZH2 forms interaction with Forkhead box M1 (FoxM1) to promote the expression of MMPs, thus establishing a functional switch from PRC2(EZH2) towards the EZH2:FoxM1-dependent activation of genes related to tumor cell invasion (Figure 3a and Table 2) [72]. This evidence concerns the gene FOXM1 and neoplasm.