In our previous study, the loss of Txnip in innate immune cells, such as neutrophils and macrophages, did not result in any differences in the production of proinflammatory cytokines under direct stimulation with PAMPs or bacterial infection in vitro; however, even though KO mice had fewer NK cells, compared with WT mice, KO mice showed similar production levels of proinflammatory cytokines and were hypersusceptible to endotoxic shock [28]. The gene discussed is TXNIP; the disease is bacterial infectious disease.