TP53 and breast cancer: As indicated in Table 1, Chompret criteria include, in particular, (i) the familial aggregation of a patient with breast cancer before 46 years and at least one first- or second-degree relative with a TP53 core tumour before 56 years, (ii) the development of breast cancer before 46 years and a second tumour and (ii) the occurrence of very early-onset breast cancer, occurring before 31 years.