CCND1 and colorectal cancer: For example, extract of M. alba root bark induces cell growth arrest and apoptosis in SW480 human colorectal cancer cells by activating ATF3 expression and down-regulating cyclin D1 level [32], and also reduces the viability of multidrug-resistant MCF-7/Dox cells by inhibiting YB-1-dependent MDR1 expression [33].