AKT1 and non-small cell lung carcinoma: For example, piroxicam, a traditional non-steroidal anti-inflammatory drug, causes apoptosis by ROS-mediated AKT activation, and artocarpin, an isoprenyl flavonoid, induces apoptosis via the ROS-mediated activation of MAPKs and AKT in non-small cell lung cancer cells [47,48].