HNC0014 alone significantly delayed the tumor growth and showed even better results when combined with the anti-PD-L1 antibody; this is conceivable since HNC0014 reduced CD44, β-catenin c-Met, and its phosphorylated form (c-Metp), all of which are contributors towards immune suppression [38,46,47]. The gene discussed is CD274; the disease is neoplasm.