Suprisingly and in contrast with the other findings, the repression of Vegfa in adult mice also resulted in impressive browning of the epididymal WAT (eWAT) and a resistance to HFD-induced obesity, suggesting a role for VEGFA in energy metabolism, which is currently not completely understood [76] (Figure 3). Here, VEGFA is linked to obesity due to melanocortin 4 receptor deficiency.