Curcumin can also act through the Nfr2/FXR/LXRalpha pathway to regulate the expression of CYP3A and CYP7A as well as alter the expression of CD36, sterol regulatory element-binding protein-1c (SREBP-1c), and FAS to regulate cholesterol and fatty acid metabolism in NAFLD [62]. This evidence concerns the gene SREBF1 and metabolic dysfunction-associated steatotic liver disease.