In a double-blind, placebo-controlled, randomized, 16 week clinical study of non-diabetic, obese premenopausal women with and without NAFLD, PSO mixed with brown marine algae fucoxanthin resulted in a significant reduction of body weight, liver fat content, liver enzymes, serum triglycerides, and C-reactive protein in the NAFLD group [71]. Here, CRP is linked to metabolic dysfunction-associated steatotic liver disease.