Nrf2 deficient mice showed a substantial increase in hepatic steatosis, hepatic oxidative stress, an increase in hepatic NF-kappaB p65 protein, and an increase in inflammatory markers tumor necrosis factor-α (TNFα), cyclooxygenase 2, and inducible nitric oxide synthase as compared to livers from wild-type mice [50]. Here, TNF is linked to fatty liver disease.