MTO supplementation in dietary-induced obese mice prevented several of the cardiovascular and metabolic pathologies in dietary obesity such as excessive weight gain, hyperglycemia, and hypertension and also decreased obesity-induced hepatic fibrosis through decreases in matrix metalloproteinase-2 (MMP2) and 9 [74]. This evidence concerns the gene SELENBP1 and obesity due to melanocortin 4 receptor deficiency.