Studies with natural Nrf2 inducers such as sulforaphane and its precursor glucoraphanin as well as glycycoumarin (GCM) which is a representative coumarin compound in licorice have demonstrated the hepatoprotective effects of these compounds in both models of NAFLD as well as NASH [54,55]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.