In our current study, we tested our hypothesis on CD74-regulated inflammatory markers’ expression, CD74 itself, MIF, iNOS, nitrotyrosine (NT), cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES1) in stage IV melanoma tumors and found that some are associated with survival outcome and the risk of developing CNS metastasis. This evidence concerns the gene NOS2 and melanoma.