It is well known that increased plasma PAI-1 expression and decreased tPA activity are thought to play important roles in the development of MetS.[36] Increased PAI-1 levels have been shown to be associated with many risk factors such as central obesity, hypertension, dyslipidemia, and glucose intolerance, collectively referred to as MetS.[27,37–39]. The gene discussed is SERPINE1; the disease is Abdominal obesity.