IL-6 (–572) GC genotype shared a negative association with HCC development among HBV carriers.[17] In a study of Han population, the authors found that –572G>C polymorphism of IL-6 gene was associated with susceptibility to HBV-related HCC in a male Chinese participant cohort.[18] Consistent with previous studies,[16] we found no significant association between IL-6 –572G>C polymorphism and risk of HCC in this meta-analysis. This evidence concerns the gene IL6 and hepatocellular carcinoma.