Interleukin-6 (IL-6) is a multifunctional potent pleiotropic inflammatory cytokine and a major driver of hepatocyte repair and replication, which is also a critical mediator of HCC development.[10] In diethylnitrosamine induced mouse model of HCC, IL-6 was demonstrated to play very critical roles in both malignant transformation of HCC progenitor cells and HCC growth.[8,12] IL-6 can signal through 2 distinct pathways: the IL-6 classic and the IL-6 trans-signaling pathway. Here, IL6 is linked to hepatocellular carcinoma.