In codominant (GG vs CC: OR = 3.49, 95% CI = 1.48–8.21, P = .004, I2 = 0%), recessive (GG+GC vs CC: OR = 3.07, 95% CI = 1.37–6.88, P = .006, I2 = 3%), and allele (G vs C: OR = 1.64, 95% CI = 1.15–2.34, P = .007, I2 = 45%) models, IL-6 –174G>C polymorphism was significantly associated with the risk of HCC, which was absent in dominant model (GG vs CC+GC: OR = 1.68, 95% CI = 0.89–3.17, P = .11, I2 = 73%) (Fig. 5). This evidence concerns the gene IL6 and hepatocellular carcinoma.