Twin studies showed that the heritability of CHD is estimated to be between 41% and 77%.[12] More recently, researchers have proposed genetic risk factors for CHD, which can be identified by the robust genome-wide association studies.[13] In addition, genome-wide association studies showed that there are numerous candidate genes and considerable single nucleotide polymorphisms remarkably associated with CHD, such as VEGF,[14] SCARB1,[15] ADAMTS-7,[16] SCARB1,[17] VEGFA,[18] MADD-FOLH1,[19] CYPs,[20] and APOC3.[21]. This evidence concerns the gene MADD and coronary artery disorder.