In these 8 active compounds, Triptolide has been shown to have a therapeutic effect on AML.[9,10] Triptolide can inhibit the expression of MDM2 and lead to the p53-dependent pathway inhibition and thus achieve the curative effect on AML.[32] Other active ingredients in TW have also been shown to have therapeutic effects on other cancers. The gene discussed is MDM2; the disease is acute myeloid leukemia.