Such as Hederagenin, it can inhibit the proliferation of cervical cancer CaSki cells and promote their apoptosis by blocking the STAT3 pathway.[33] And Isoxanthohumol can inhibit the formation of lung metastasis in B16-F10 murine melanoma model.[34] Tripterygium also exhibited significant inhibitory effects on many cancer cells.[35]. This evidence concerns the gene STAT3 and melanoma.