Diabetes mellitus is a group of metabolic diseases with chronic hyperglycemia, which is caused by the deficiency of insulin secretion and insulin function.[1] Epidemiological statistics results show a clear increase on the prevalence of diabetes mellitus in China, with the proportion of people with diabetes mellitus increasing from <1% of the total population in 1980 to 10.4% in 2013. Here, INS is linked to metabolic disease.