TPO and hematocrit: Cytological studies have also confirmed that abnormal activation of NF - κ B may be closely related to the pathogenesis of HT.[18] Prunella can inhibit the activation of transcription factor NF - κ B.[19] The results of animal experiments showed that in terms of regulating the efficacy of thyroid hormone, pvae could intervene to down regulate the levels of TSH, TG AB, and TPO AB in rat plasma.[20]