APPL1 and Insulin resistance: For example, adiponectin attenuated neuronal apoptosis through AdipoR1/APPL1/LKB1/AMPK signaling pathway.[23] Adiponectin aggravated atherosclerosis by inhibiting the AdipoR1-AMPK-iNOS pathway in adventitial fibroblasts.[24] Furthermore, PPAR caused an improvement in obesity-induced insulin resistance by activating adiponectin-AdipoRs.[25] These data are consistent with the sequencing results of our study.