As it demonstrated that Kit mutated in a fully clonal manner and Arid1a mutated heterogeneously, Kit mutation may precede Arid1a mutation.[17] Moreover, while Kit mutated universally in gastrointestinal stromal tumors (GIST), only a portion of GIST harbored mutations of Arid1a,[18] indicating ARID1A may act as a downstream protein of KIT-related pathways. This evidence concerns the gene ARID1A and gastrointestinal stromal tumor.