Furthermore, several studies have shown expression of IL-36γ is elevated upon challenge by numerous invasive bacterial and fungal pathogens, including Streptococcus pneumoniae, Klebsiella pneumoniae, Aspergillus fumigatus, and Candida albicans, and subsequent studies have implicated IL-36γ involvement in initiating an inflammatory response following infection by such organisms. The gene discussed is IL36G; the disease is infection.