As streptococcal SpeB is the most highly secreted protein produced during infection and is known to interact with host proteins with both pro- and anti-inflammatory consequences, the data presented here may well provide a mechanistic link between the proteolytic activation of IL-36γ by S. pyogenes SpeB and the initiation of guttate psoriasis (Nelson et al., 2011; Elliott, 1945). The gene discussed is IL36G; the disease is psoriasis.