CD4 and parasitic infectious disease: Because of this divergence in parasitemia (day 14 p.i.; Figure 1A) around the onset of the adaptive immune response and the critical role of GC-dependent antibody production for the clearance of Plasmodium-infected RBCs (Blackman et al., 1990; Hill et al., 2013), we hypothesized that resistant mice would exhibit increased numbers of antigen-specific CD4 T cells, Tfh cells, plasmablasts, and GC B cells.