Given that the tumor microenvironment is a complex community of multiple different cell types that interact to affect tumor cell behavior, including survival, proliferation, motility and autocrine and paracrine signaling, it will be important to investigate the LNas1 and LNbs1 sublines in the context of the tumor microenvironment to determine if chronic IL-1 exposure provides a growth advantage in vivo. This evidence concerns the gene IL1B and neoplasm.