Interestingly, Yu et al. observed tumor growth over a 6 week period using a LNCaP xenograft model and found that androgen deprivation induced PCa cell IL-1β secretion, leading to mesenchymal stem cell (MSC) recruitment, MSC CCL5 secretion and CCL5-dependent CRPCa development [12]. This evidence concerns the gene CCL5 and posterior cortical atrophy.