EGF and posterior cortical atrophy: For example, EGF [38], AMPK [39], Wnt/Ca2+ [40], NGF [41], FGF [42], and ILK [43] signaling pathways promote PCa survival, tumorigenicity or castration resistance and are predicted to be constitutively high in the IL-1 sublines as compared to LNCaP cells (z-score ≥ 3.0, -log p-value ≥ 1.33) (S1 Table) and RT-qPCR confirms high basal expression of genes that mediate one or more of these pathways (S1 Table; S2 Fig).